Endocrine Abstracts

Introduction: Adrenal incidentalomas (AIs) constitute an emerging clinical entity due to the increased use of abdominal imaging for diagnostic purposes.Objective: To investigate the morphological and hormonal alterations of AIs in a cohort of patients, who were followed-up in a single centre.Methods: Sixty-four patients (22 males and 42 females; mean age 61.6±1.2 years), with AIs and follow-up of 3.1±0.4 years (range 0&#1...

Introduction: Type 2 diabetes mellitus (T2DM) and osteoporosis may co-exist in the same individual. However, the exact effect of anti-osteoporotic treatment on glucose metabolism is unknown. We aimed to systematically review the effects of anti-osteoporotic medications on glucose metabolism and the incidence of T2DM.Methods/design: PubMed, Cochrane and EMBASE were systematically searched until the 31 of December, 2017.Results: ...

Introduction: Early menopause (defined as age of menopause <45 years) and premature ovarian failure (defined as age of menopause <40 years) are associated with accelerated bone loss and increased risk of osteoporosis in later life. However, their association with increased fracture risk has not been established, with studies yielding conflicting results. The aim of this study was to systematically review and meta-analyze studies evaluating the effect of age at onset of...

Introduction: The aim of this study was to investigate the degree of atherosclerosis in women of reproductive age with type 2 diabetes mellitus (T2DM), with and without polycystic ovary syndrome (PCOS).Patients and Methods: 71 women (mean age 43.2 y) with T2DM treated with diet or oral anti-diabetic medications and 36 controls were studied. According to menstrual cycle and clinical hyperandrogenism, patients with T2DM were classified into two subgroups, ...

ObjectiveThe exact risk of type 2 diabetes in women with polycystic ovary syndrome (PCOS) is unknown. It is also unclear if obesity independently increases the risk in this population. The aim of this study was to systematically review and synthesize the best available evidence regarding the association between PCOS and type 2 diabetes, stratified according to obesity status.MethodsA comprehensive search was ...

PurposeRadioactive iodine (RAI) is frequently used as adjuvant therapy in patients with differentiated thyroid cancer (DTC). However, its effect on ovarian reserve has not been fully elucidated, with studies yielding inconsistent results. The aim of this study was to systematically review and meta-analyze the best available evidence regarding the effect of RAI on ovarian reserve in premenopausal women with DTC.Methods<p class="...

ContextWhether pre-operative vitamin D deficiency (VDD) contributes to post-operative hypoparathyroidism (hypoPT) risk is unknown.ObjectiveTo meta-analyze the best available evidence regarding the association between pre-operative vitamin D status and hypoPT risk.Data SourcesA comprehensive literature search was conducted in PubMed, CENTRAL and Scopus databases, u...

Objective: Menopausal hormone therapy (MHT) is efficacious in reducing the risk of vertebral, non-vertebral and hip fractures, irrespective of age, falls risk or baseline FRAX probability. However, the optimal sequential anti-osteoporotic treatment after MHT discontinuation has not yet been designated. This systematic review aimed to obtain the best evidence regarding the effect of antiresorptive or osteoanabolic treatment on bone mineral density (BMD) and/or fracture risk fol...

Introduction: Hashimoto’s thyroiditis raises the risk for thyroid cancer (TC) in surgical series, but the role of thyroid peroxidase antibodies (TPO) remains controversial in that regard. We designed the present study to evaluate the effect of preoperative TPO titers in the risk of DTC.Methods: A comprehensive search was conducted in PubMed, CENTRAand Scopus databases in November 2021 for the terms “thyroid cancer” and “TPO” or &...

Aim: To investigate reproductive function disorders in young women with type 1 diabetes mellitus (T1DM).Patients and methods: We studied 53 women with T1DM (duration 8.0±5.6 y) and 51 healthy controls with normal menstrual cycles and no clinical hyperandrogenism, matched for age (19.4±4.3 vs 20.8±3.1 years, P=0.063) and body mass index (BMI) (22.2±2.7 vs 21.4±1.9 kg/m2, P=0.088). T1DM (insulin regimen...